Chemotherapy dosing in obese patients

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August undefined, 2024

WebMay 1, 2014 · Understandably, dosing chemotherapy in obese cancer patients is a common issue. Chemotherapy used as part of conditioning therapy before hematopoietic stem cell transplantation (HCT) has multiple purposes. In the autologous setting, the goal is primarily to reduce tumor burden, but in the allogeneic setting, there is the additional … WebJul 16, 2013 · With increasing rates of obesity, and variation and uncertainty about appropriate dosing of chemotherapy in obese patients, ASCO has generated clinical practice guidelines for appropriate ...

Appropriate Chemotherapy Dosing for Obese Adult …

WebMay 3, 2024 · PURPOSE To provide recommendations for appropriate dosing of systemic antineoplastic agents in obese adults with cancer. METHODS A systematic review of the literature collected evidence regarding dosing of chemotherapy, immunotherapy, and … Web•Chemotherapy dose selection is not generally a shared decision between prescribers and patients. •Obese patients do, however, experience stigma and weight-based implicit … porterhouse buckingham

Frontiers Obesity and Dose of Anti-cancer Therapy: Are We Sure …

WebOct 25, 2024 · The prevalence of overweight and obese patients was 29% in childhood brain tumor survivors in comparison to 13% in the general pediatric population . ... Children With Embryonal Brain Tumors After Risk-Adapted Craniospinal and Conformal Primary-Site Irradiation and High-Dose Chemotherapy With Stem-Cell Rescue on the SJMB-96 Trial. … WebIt is important to evaluate the effect on chemotherapy agents given their narrow therapeutic window. Dose capping has been used to limit excess toxicity in obese patients at the risk of providing a less-effective regimen. Data suggest an increased dose of carboplatin, cisplatin, ifosfamide, paclitaxel, and vincristine may be needed in obese ... WebApr 28, 2008 · The BSA is, in turn, calculated by using height and weight according to one of several methods. 1 Although the majority of overweight and obese women are treated with full weight-based chemotherapy doses, the practice of administering reduced doses (compared with those doses that would be expected if actual weight were used to … porterhouse brunch buffet 自助餐

Appropriate chemotherapy dosing in obese patients with cancer

(PDF) To Cap or Not to Cap: Chemotherapy Dosing in Obese …

WebNo data on overweight or obese RDI Patients with aggressive-histology NHL treated with CHOP and CHOP-like chemotherapy in clinical practices throughout the United States … WebApr 6, 2024 · Calculation of chemotherapy dosing using body weight or body surface area (BSA) may be adjusted in obese patients due to concern for treatment-related toxicities [3, 4], despite The American ... op shops waihiWebOct 21, 2024 · Griggs JJ, Mangu PB, Anderson H, et al. Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical … op shops ulverstone

"WebOct 8, 2013 · Oncol. 10, 451–459; 2013), 1 which raised some important issues on the effect of sarcopenia on chemotherapy-related toxicity in obese patients with cancer (Sarcopenia and chemotherapy dosing in ... " - Chemotherapy dosing in obese patients

Chemotherapy dosing in obese patients

Conditioning Chemotherapy Dose Adjustment in Obese Patients…

WebApr 3, 2012 · Such arbitrary dose adjustments are major factors associated with reduced chemotherapy dose intensity received by obese patients with cancer. 26,28 Most of the reduction in dose intensity associated … WebIt is important to evaluate the effect on chemotherapy agents given their narrow therapeutic window. Dose capping has been used to limit excess toxicity in obese patients at the …

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Webincreased NRM in obese patients. Conclusion Dose adjustment in obese autologous HCT patients does not increase risk for disease relapse. [23] No differences in OS between … WebThe review found that dose adjustments for obesity have, to date, been based empirically or extrapolated from published data in the nontransplantation patient population. As a …

WebThe high toxicity may be due to the BSA-based chemotherapy dose adjustment, since large BSA typical of obese patients corresponds to high drug dose which is disproportionate for a body with very depleted lean mass . Further evaluations through diagnostic imaging techniques are considered the only valid measurements to gain … WebNov 15, 2013 · Thus, appropriate chemotherapy dosing for obese patients with malignant diseases is a significant issue. Limiting chemotherapy doses in overweight and obese …

WebApr 11, 2024 · Then the American Society of Clinical Oncology (ASCO) conducted an extensive review of published studies about chemotherapy dosing for obese or overweight patients. Based on data from those studies, in 2011 ASCO published guidelines advising that, unless there are complicating factors, "we use actual body weight for the patient, … WebMethods: In a multicenter trial in Canada, we randomized 301 patients with breast cancer initiating chemotherapy to thrice weekly, supervised exercise consisting of either a standard dose of 25 to 30 minutes of aerobic exercise (STAN; n ¼ 96), a higher dose of 50 to 60 minutes of aerobic exercise (HIGH; n ¼ 101), or a

WebNov 15, 2013 · Thus, appropriate chemotherapy dosing for obese patients with malignant diseases is a significant issue. Limiting chemotherapy doses in overweight and obese patients may negatively influence the outcomes in these patients. ASCO has recently published clinical practice guidelines for conventional chemotherapy dosing for obese …

WebAll formulas resulted in carboplatin dosing of more than ±20% of target dose in a fifth of all patients. However, the Cockcroft and Gault equation (with ideal body weight) was the … op shops upper huttWebJul 16, 2013 · ASCO conducted an exhaustive review of the literature on chemotherapy dosing in obese patients with cancer. 44 Based on this review, clinical practice … op shops victor harborWebOct 29, 2012 · Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 2012; 30: 1553–1561. op shops werribeeWebOct 26, 2012 · Weight-based chemotherapy dosing in obese patients with cancer: back to the future [published online ahead of print April 3, 2012]. J of Oncol Pract. 2012;8(4):62e … porterhouse building and fire solutions ltdWebJul 1, 2024 · Chemotherapy dose reduction, non-weight-based, or capped dosing strategies are common practice among oncologists prescribing treatment for overweight … op shops whanganuiWebAll formulas resulted in carboplatin dosing of more than ±20% of target dose in a fifth of all patients. However, the Cockcroft and Gault equation (with ideal body weight) was the least concordant, and it was significantly discordant in obese patients (body mass index >30 kg/m 2), resulting in underdosing of carboplatin . porterhouse burger greensboro pisgah churchWebJul 5, 2024 · The findings support the "recently published ASCO guidance that full, weight-based chemotherapy doses should be used to treat obese adult patients," she commented. "Adjuvant chemotherapy has the ... op shops yanchep