Chromopyrrolic
WebAug 19, 2007 · 2R0C, 2R0G, 2R0P. PubMed Abstract: The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one … WebJun 6, 2007 · Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Staurosporine isolated from Streptomyces sp. …
Chromopyrrolic
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WebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid. Journal Of The American Chemical Society, 128 (37). 12289-12298 doi:10.1021/ja063898m WebJun 12, 2014 · With this methodology, several key intermediates of natural products have been effectively prepared, and the total syntheses of lycogarubin C and chromopyrrolic acid have been completed in high efficiency. Supporting Information Spectral data ( 1 H and 13 C) and data for the X-ray analysis.
WebApr 1, 2009 · The ‘open’ chromopyrrolic acid intermediate must be now converted into a ‘closed’ indolocarbazole aglycone either containing an imide (rebeccamycin-like as in arcyriaflavin A) or an amide (staurosporine-like as in K252c) function at the pyrrole moiety. This requires an enzyme pair that is present in all four clusters (RebC/RebP, StaC ... WebAs a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme. As a reactant in the Biginelli-like scaffold syntheses. Packaging. 250, 500 mg. 1, 5 g in poly bottle. Linkage. α-Keto analogue of tryptophan. Safety Information. Pictograms. GHS07. Signal Word. Warning.
WebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; … Chromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial metabolite. It is a member of indoles and a pyrroledicarboxylic acid.
Webring rearrangement from indole-3-pyruvic acid and NH4+ by the action of chromopyrrolic acid synthase (VioB or StaD) (Asamizu et al. 2007; Hirano et al. 2008). C. violaceum genome analysis showed that the genes trpA–F and pabA–B encode the anthranilate synthase in the tryptophan pathway in the conversion of chorismate to anthranilate (see ...
WebJun 12, 2014 · This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced was somewhat smaller. The structure of chromopyrrolic acid was closely related to that of violacein and deoxyviolacein. The pyrrole dicarboxylic acid moiety of chromopyrrolic … how to remove thread view from outlookWebChromopyrrolic Acid. Chromopyrrolic acid (55) formation is catalyzed by the chromopyrrolic acid synthase ClaD. From: The Alkaloids: Chemistry and Biology, … how to remove threats from windows defenderWebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T. Biosci. Biotechnol.... how to remove threat from windows defenderWebchlorination of chromopyrrolic acid or arcyriaflavin was detected when we fed either of these compounds to a S. albus strain expressing rebH. In contrast, coexpression of rebODH or rebOD-CPH yielded chloro and dichloro versions of chromopyrrolic acid (compounds 7 and 10), A S. albus andA ... how to remove threatlockerWebSep 25, 2007 · In the chromopyrrolic acid-soaked structure, residues 1 and 2 and 246–250 (of Chains A and B) and 418–421 (of Chain B) were not included in the model. In this … how to remove threaded screwWeb开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 norman reedus 1990Webchromopyrrolic acid (CHEBI:41625) ChEBI > Main CHEBI:41625 - chromopyrrolic acid Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models Formula … norman rayford day 2022