Robo1 overexpression

Author: xsdb

August undefined, 2024

WebOverexpression of ROBO1 can inhibit the proliferation of PC cells in vitro, and the S phase fraction can also be induced. Further subcutaneous tumor formation in nude mice showed that ROBO1 overexpression can significantly inhibit tumor growth. YY1 was found to directly bind to the promoter region of ROBO1 to promote transcription by a ... WebIncreases in culture intervals significantly increased expression of SFRP2, PRRX1 genes and some other genes involved in inflammatory process, such as: CCL2, IL6, and ROBO1. …

PD-L1 Expression as a Predictive Biomarker in Cancer …

WebMar 2, 2024 · ROBO1 expression is positively correlated with multiple immune checkpoint molecules, suggesting that ROBO1 may be a potential drug target to enhance the potency of immunotherapy. The miR-152-3p/ ROBO1 signalling axis contributes to malignant progression and provides a prospective immunotherapeutic target for HCC. WebNov 26, 2015 · Overexpression of ROBO1 or ROBO2 produces anti-proliferative and pro-apoptotic effects in leukaemia cells in vitro. ROBO mutations are independent factors for predicting poor survival. The... alici betreuer

Whole-exome and targeted sequencing identify ROBO1 …

WebMar 13, 2024 · The expression of ROBO1 was higher in cancer tissues than in matched adjacent tissues by immunohistochemistry (IHC) and qRT-PCR. Low ROBO1 expression is … Web1 day ago · 3 pts had stable disease (1 with EGFR overexpression and gene CNA; 2 not evaluable for IHC), with tumor reductions of 2%, 17%, and 40%. Petosemtamab continues to demonstrate a manageable safety ... WebOverexpression of wild-type ROBO1 and the ROBO1 R77H mutant (a,c), as well as wild-type ROBO2 and the ROBO2 G107E mutant (b,d), induced an increase in apoptosis in K562 (a,b) and HEL (c,d) cells. alici cantabrico

[Robo1 expression in breast cancer and its relationship to brain ...

Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in …

WebJan 24, 2024 · In this study, upregulated expression of circROBO1 was found in BC-derived liver metastases and was correlated with poor prognosis. Knockdown of circROBO1 strikingly inhibited the proliferation, migration, and invasion of BC cells, whereas overexpression of circROBO1 showed the opposite effects. WebFeb 15, 2024 · The results demonstrated that ROBO1-FL-expressing tumour cells showed increased proliferation and colony formation ability in the presence of recombinant SLIT2 (rSLIT2), and this advantage could... aliciazzzhttp://www.cancerindex.org/geneweb/ROBO1.htm alici cantabriche

"WebFor the colony formation assay, Huh7 and Hep3B cells transfected with si-TRIM52-AS1, miR-218-5p inhibitor and ROBO1 overexpression vector were seeded in each well of a six-well plate and cultured in the appropriate medium containing 10% FBS. After 14 days, the colonies were fixed with paraformaldehyde and stained with 0.2% crystal violet. " - Robo1 overexpression

Robo1 overexpression

Entry - *602430 - ROUNDABOUT GUIDANCE RECEPTOR 1; …

WebApr 3, 2024 · The ROBO1 gene encodes a receptor that is a member of the neural cell adhesion molecule (NCAM; 116930) family of receptors. ROBO1 acts as an axon guidance receptor that defines a novel subfamily of immunoglobulin superfamily proteins that is highly conserved from fruit flies to mammals ( Kidd et al., 1998 ). Cloning and Expression WebObjective: To detect the expression of Robo1 in different breast tumors and its association with the breast cancer brain metastasis. Methods: Labelled streptavidin-biotin (LSAB) …

Did you know?

WebOct 14, 2024 · The ROBO1 gene is located on chromosome 3p12.3 and consists of 35 exons. It encodes an integral membrane protein that is a member of the immunoglobulin gene superfamily. ROBO1 is reported to have an oncogenic function in certain malignancies. For example, the amplification of ROBO1 causes chordoma cells to become invasive and … WebNov 10, 2024 · ROBO1 is expressed in both luminal and basal cells, but loss of Robo1 in basal cells results in the luminal differentiation defect. In the basal compartment, ROBO1 inhibits the expression of Notch ligand Jag1 by regulating β-catenin (CTNNB1), which binds the Jag1 promoter.

WebThe expression of miR-490-5p was down-regulated, while ROBO1 was up-regulated in HCC tissues and cells than the controls. MiR-490-5p can target ROBO1. MiR-490-5p inhibited … WebThrough modulating the activity of ROBO1, ROBO2, ROBO4, Src, and vascular endothelial growth factor (VEGF) pathway, endothelial cell behaviors, including tube formation and filopodia formation ...

WebCirc_USP36 knockdown reduced ROBO1 expression partly by up-regulating miR-197-3p in HUVECs. ROBO1 overexpression reversed miR-197-3p accumulation-mediated effects in ox-LDL-induced HUVECs. In conclusion, circ_USP36 interference alleviated ox-LDL-induced dysfunction in HUVECs by targeting miR-197-3p/ ROBO1 axis. WebMar 13, 2024 · Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, is a group 1 carcinogen that introduces mutagenic DNA adducts into the genome. In this study, we investigated the molecular mechanisms underlying the involvement of silymarin in the reduction of DNA adduct formation by B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), induced …

Websubpopulation with CD94/NKG2C overexpression and decreased expression of PD-1, TIGIT and NKG2A checkpoint receptors [26,27]. The CD56dim/CD16bright/CD94/NKG2C cells …

WebThe ROBO1 gene is located on chromosome 3p12.3 and consists of 35 exons. It encodes an integral membrane protein that is a member of the immunoglobulin gene superfamily. … aliciclica oq éWebTwo previously identified reading-related ROBO1 polymorphisms were genotyped, and diffusion and structural MRI were acquired to measure the fiber microstructure of the … aliciclicoWebNov 26, 2015 · Overexpression of ROBO1 or ROBO2 produces anti-proliferative and pro-apoptotic effects in leukaemia cells in vitro. ROBO mutations are independent factors for … aliciclica ciclicaWebRobo proteins are a class of transmembrane receptor proteins with 1000 to 1600 amino acids and have highly conserved intracellular domains with no autocatalytic or intrinsic enzymatic activity. aliciclicasWebMar 10, 2024 · In breast cancer progression is also involved circ-ROBO1 (has_circ_0124696), which promotes breast cancer-derived liver metastasis by sponging ... that functions as a sponge of the pro-EMT regulators miR-429 and miR-200b-3p. Conversely, circPTK2 overexpression significantly decreases the expression of Snail and limits the … alici come cucinarle alici e funghiWebTo further investigate whether circROBO1 promoted the proliferation of HCC cells by upregulating CCNT2, we constructed a co-transfection system of circROBO1 shRNA and … aliciclica alifatica